Ontology highlight
ABSTRACT:
SUBMITTER: Caetano MS
PROVIDER: S-EPMC6214980 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Caetano Mauricio S MS Hassane Maya M Van Hieu T HT Bugarin Emmanuel E Cumpian Amber M AM McDowell Christina L CL Cavazos Carolina Gonzalez CG Zhang Huiyuan H Deng Shanshan S Diao Lixia L Wang Jing J Evans Scott E SE Behrens Carmen C Wistuba Ignacio I II Fuqua Susan A W SAW Lin Huang H Stabile Laura P LP Watowich Stephanie S SS Kadara Humam H Moghaddam Seyed Javad SJ
Nature communications 20181102 1
Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout (LR/Stat3<sup>Δ/Δ</sup>) mouse model. Epithelial Stat3 deletion results in intriguing sex-associated discrepancies; K-ras mutant tumors are decreased in female LR/Stat3<sup>Δ/Δ</sup> mice whereas tumor burdens are ...[more]