Ontology highlight
ABSTRACT:
SUBMITTER: Tuteja M
PROVIDER: S-EPMC6215448 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Tuteja Mohit M Kang Minjee M Leal Cecilia C Centrone Andrea A
The Analyst 20180801 16
Paclitaxel is a powerful drug against restenosis and many forms of cancer. However, its clinical application hinges on the ability to achieve suitable stabilized drug concentrations in an aqueous suspension while hindering drug crystallization. To engineer such formulations, it is imperative to understand paclitaxel's partitioning and crystallization within the carrier matrix. Lipid-polymer hybrid films have been recently shown to accommodate large paclitaxel loads and suppress crystallization. ...[more]