Neoantigens in Ovarian Cancer: Embarrassment of Riches or Needles in a Haystack?
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ABSTRACT:
SUBMITTER: McNeish IA
PROVIDER: S-EPMC6215482 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Neoantigens in Ovarian Cancer: Embarrassment of Riches or Needles in a Haystack?
Clinical cancer research : an official journal of the American Association for Cancer Research 20180706 22
Comprehensive genomic and transcriptomic analysis demonstrate that tumor-infiltrating T lymphocytes that react to mutated neoepitopes could be identified in recurrent ovarian cancer. Two of these T-cell populations reacted against <i>TP53</i> hotspot missense mutations that are present in a wide variety of malignancies. <i>Clin Cancer Res; 24(22); 5493-5. ©2018 AACR</i> <i>See related article by Deniger et al., p. 5562</i>. ...[more]
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