Dataset Information

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

ABSTRACT:

Background

We investigated the radiologic and clinical findings of radial scar and complex sclerosing lesions, and evaluated the rate of pathologic upgrade and predicting factors.

Methods

From review of our institution's database from January 2006 to December 2012, we enrolled 82 radial scars/complex sclerosing lesions in 80 women; 51 by ultrasound guided core needle biopsy, 1 by mammography-guided stereotactic biopsy, and 38 by surgical excision. The initial biopsy pathology revealed that 53 lesions were without high risk lesions and 29 were with high risk lesions. Radiologic, clinical and pathological results were analyzed statistically and upgrade rates were calculated.

Results

Of the 82 lesions, 64 (78.0%) were surgically excised. After surgical excision, two were upgraded to DCIS and two were upgraded to lesions with high risk lesions. The rate of radial scar with high risk lesions was significantly higher in the surgical excision group (11.1% vs. 42.2%, p?=?0.015), which also demonstrated larger lesion size (10.7?±?6.5 vs. 7.1?±?2.6 mm, p?=?0.001). The diagnoses with high risk lesions on final pathological results showed older age (52.9?±?6.0 years vs. 48.4?±?6.7 years, p?=?0.018).

Conclusions

Radial scars with and without high risk lesions showed no statistically significant differences in imaging, and gave relatively low cancer upgrade rates.

SUBMITTER: Ha SM

PROVIDER: S-EPMC6215659 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Ha Su Min SM Cha Joo Hee JH Shin Hee Jung HJ Chae Eun Young EY Choi Woo Jung WJ Kim Hak Hee HH Oh Ha-Yeon HY

BMC medical imaging 20181103 1

<h4>Background</h4>We investigated the radiologic and clinical findings of radial scar and complex sclerosing lesions, and evaluated the rate of pathologic upgrade and predicting factors.<h4>Methods</h4>From review of our institution's database from January 2006 to December 2012, we enrolled 82 radial scars/complex sclerosing lesions in 80 women; 51 by ultrasound guided core needle biopsy, 1 by mammography-guided stereotactic biopsy, and 38 by surgical excision. The initial biopsy pathology reve ...[more]

PMID: 30390667

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Project description:The identification as well as the molecular characterization of breast precancerous lesions in terms of increased risk of progression and/or recurrence is becoming a critical issue today as improved non-surgical procedures are detecting cancer at an earlier stage. The strategy we have been pursuing to identify early apocrine breast lesions is based on the postulate that invasive apocrine carcinomas evolve from epithelial cells in terminal duct lobular units (TDLUs) in a stepwise manner that involves apocrine metaplasia of normal breast epithelia, hyperplasia, atypia, and apocrine carcinoma in situ. First, we identify specific protein biomarkers for benign apocrine metaplasia and thereafter we search for biomarkers that are highly overexpressed by pure invasive apocrine carcinomas. Here we present studies in which we have used antibodies against components of a benign apocrine signature that includes 15-prostaglandin dehydrogenase (15-PGDH), a protein that is expressed by all benign apocrine lesions, and markers that are highly overexpressed by pure invasive apocrine carcinomas such as MRP14 (S100A9), psoriasin (S100A7), and p53 to identify precancerous lesions in sclerosing adenosis (SA) with apocrine metaplasia. The latter is a benign proliferative lesion of the breast that exhibits an increase in the size of the TDLUs and characterized by retained two-cell lining, and myoepithelial (ME) and stromal hyperplasia. SA with apocrine metaplasia, i.e. apocrine adenosis (AA), presents with a higher degree of atypical apocrine hyperplasia, and these lesions are believed to be precursors of apocrine carcinoma, in situ and invasive. Analysis of 24 selected SA samples with apocrine metaplasia revealed non-obligate putative apocrine precancerous lesions that displayed some, or in same cases all the three markers associated with pure invasive apocrine carcinomas. These studies also revealed p53 positive, non-apocrine putative precancerous lesions as well as novel phenotypes for ME and some luminal cells characterized by the expression of cytokeratin 15.

Dataset Information

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Background

Methods

Results

Conclusions

Publications

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Similar Datasets

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