Dataset Information

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

ABSTRACT:

Background

We investigated the radiologic and clinical findings of radial scar and complex sclerosing lesions, and evaluated the rate of pathologic upgrade and predicting factors.

Methods

From review of our institution's database from January 2006 to December 2012, we enrolled 82 radial scars/complex sclerosing lesions in 80 women; 51 by ultrasound guided core needle biopsy, 1 by mammography-guided stereotactic biopsy, and 38 by surgical excision. The initial biopsy pathology revealed that 53 lesions were without high risk lesions and 29 were with high risk lesions. Radiologic, clinical and pathological results were analyzed statistically and upgrade rates were calculated.

Results

Of the 82 lesions, 64 (78.0%) were surgically excised. After surgical excision, two were upgraded to DCIS and two were upgraded to lesions with high risk lesions. The rate of radial scar with high risk lesions was significantly higher in the surgical excision group (11.1% vs. 42.2%, p?=?0.015), which also demonstrated larger lesion size (10.7?±?6.5 vs. 7.1?±?2.6 mm, p?=?0.001). The diagnoses with high risk lesions on final pathological results showed older age (52.9?±?6.0 years vs. 48.4?±?6.7 years, p?=?0.018).

Conclusions

Radial scars with and without high risk lesions showed no statistically significant differences in imaging, and gave relatively low cancer upgrade rates.

SUBMITTER: Ha SM

PROVIDER: S-EPMC6215659 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Ha Su Min SM Cha Joo Hee JH Shin Hee Jung HJ Chae Eun Young EY Choi Woo Jung WJ Kim Hak Hee HH Oh Ha-Yeon HY

BMC medical imaging 20181103 1

<h4>Background</h4>We investigated the radiologic and clinical findings of radial scar and complex sclerosing lesions, and evaluated the rate of pathologic upgrade and predicting factors.<h4>Methods</h4>From review of our institution's database from January 2006 to December 2012, we enrolled 82 radial scars/complex sclerosing lesions in 80 women; 51 by ultrasound guided core needle biopsy, 1 by mammography-guided stereotactic biopsy, and 38 by surgical excision. The initial biopsy pathology reve ...[more]

PMID: 30390667

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Project description:To determine whether computed tomographic (CT) attenuation values correlate with the histologic measurements of a lung cancer manifesting as a nonsolid nodule and to quantify the extent to which the tumor replaces the airspace within the nodule.Informed consent was obtained to analyze images from CT and pathologic examination under an institutional review board-approved protocol. Fifteen patients who had undergone resection of nonsolid lung cancer were evaluated. On the basis of the CT attenuation values of nonsolid nodules, nonneoplastic lung, soft tissue, and air, the overall proportion of soft tissue in the nodule and nonneoplastic lung and the difference between these two measures were calculated. The analogous measures were obtained from a representative digitized histologic slide. The area of each nodule and the proportion of air within it were measured, and the proportion of soft tissue in the nodule and nonneoplastic lung and the difference between the two were calculated. The difference between the two proportions at CT and histologic examination are the proportions attributable to the cancer on the basis of CT and histologic examinations, respectively. Linear regression was performed to assess the relationship between these measures.The average proportions of soft tissue in the nodule at CT and histologic examination were 48% and 69%, respectively, and they showed significant correlation with each other (P = .02); in addition, each showed significant correlation with the attenuation of the nodule (P < .0001 and P = .02, respectively). The difference between the proportions of soft tissue in nodule and nonneoplastic lung at CT and histologic examination were 37% and 30%, respectively, and both were independent of the tumor diameter (P = .26 and P = .41).The proportion of soft tissue within a nonsolid nodule is correlated with attenuation at CT. This allows for measurement of change within the nodule. An increase of 100 HU in nodule attenuation represents an approximately 10% increase in tumor volume.

Dataset Information

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Background

Methods

Results

Conclusions

Publications

Radial scars/complex sclerosing lesions of the breast: radiologic and clinicopathologic correlation.

Similar Datasets

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