Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cells.
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ABSTRACT:
SUBMITTER: Reed BG
PROVIDER: S-EPMC6215928 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cells.
Reed Beverly G BG Babayev Samir N SN Chen Lucy X LX Carr Bruce R BR Word R Ann RA Jimenez Patricia T PT
Reproduction (Cambridge, England) 20181201 6
MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disruptor, bisphenol A (BPA), on those miRs. miR microarray analysis and multiple confirmatory cell preparations treated with 17β-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Further, decidualization downregulated miR-27b. VEGFB and VEGFC were ...[more]
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