Ontology highlight
ABSTRACT:
SUBMITTER: Sousa C
PROVIDER: S-EPMC6216255 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Sousa Carole C Golebiewska Anna A Poovathingal Suresh K SK Kaoma Tony T Pires-Afonso Yolanda Y Martina Silvia S Coowar Djalil D Azuaje Francisco F Skupin Alexander A Balling Rudi R Biber Knut K Niclou Simone P SP Michelucci Alessandro A
EMBO reports 20180911 11
Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. Here, using a combination of single-cell RNA sequencing and multicolour flow cytometry, we comprehensively profile microglia in the brain of lipopolysaccharide (LPS)-injected mice. ...[more]