Ontology highlight
ABSTRACT:
SUBMITTER: Hong HK
PROVIDER: S-EPMC6217733 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Hong Hee-Kyung HK Maury Eleonore E Ramsey Kathryn Moynihan KM Perelis Mark M Marcheva Biliana B Omura Chiaki C Kobayashi Yumiko Y Guttridge Denis C DC Barish Grant D GD Bass Joseph J
Genes & development 20181026 21-22
The mammalian circadian clock is encoded by an autoregulatory transcription feedback loop that drives rhythmic behavior and gene expression in the brain and peripheral tissues. Transcriptomic analyses indicate cell type-specific effects of circadian cycles on rhythmic physiology, although how clock cycles respond to environmental stimuli remains incompletely understood. Here, we show that activation of the inducible transcription factor NF-κB in response to inflammatory stimuli leads to marked i ...[more]