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LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication.

ABSTRACT: How the interplay between cell- and tissue-level processes produces correctly proportioned organs is a key problem in biology. In plants, the relative size of leaves compared with their lateral appendages, called stipules, varies tremendously throughout development and evolution, yet relevant mechanisms remain unknown. Here we use genetics, live imaging, and modeling to show that in Arabidopsis leaves, the LATE MERISTEM IDENTITY1 (LMI1) homeodomain protein regulates stipule proportions via an endoreduplication-dependent trade-off that limits tissue size despite increasing cell growth. LM1 acts through directly activating the conserved mitosis blocker WEE1, which is sufficient to bypass the LMI1 requirement for leaf proportionality.

SUBMITTER: Vuolo F

PROVIDER: S-EPMC6217736 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication.

Vuolo Francesco F Kierzkowski Daniel D Runions Adam A Hajheidari Mohsen M Mentink Remco A RA Gupta Mainak Das MD Zhang Zhongjuan Z Vlad Daniela D Wang Yi Y Pecinka Ales A Gan Xiangchao X Hay Angela A Huijser Peter P Tsiantis Miltos M

Genes & development 20181026 21-22

How the interplay between cell- and tissue-level processes produces correctly proportioned organs is a key problem in biology. In plants, the relative size of leaves compared with their lateral appendages, called stipules, varies tremendously throughout development and evolution, yet relevant mechanisms remain unknown. Here we use genetics, live imaging, and modeling to show that in <i>Arabidopsis</i> leaves<i>,</i> the LATE MERISTEM IDENTITY1 (LMI1) homeodomain protein regulates stipule proport ...[more]

PMID: 30366902

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