Ontology highlight
ABSTRACT:
SUBMITTER: Sigal D
PROVIDER: S-EPMC6218237 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Sigal Daniel D Reid Jennifer N S JNS Wahl Lindi M LM
Genetics 20180904 3
We investigate the fate of <i>de novo</i> mutations that occur during the in-host replication of a pathogenic virus, predicting the probability that such mutations are passed on during disease transmission to a new host. Using influenza A virus as a model organism, we develop a life-history model of the within-host dynamics of the infection, deriving a multitype branching process with a coupled deterministic model to capture the population of available target cells. We quantify the fate of neutr ...[more]