Ontology highlight
ABSTRACT:
SUBMITTER: Balaji GR
PROVIDER: S-EPMC6218473 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181105 1
The interaction between natural killer (NK) cell inhibitory receptors and their cognate ligands constitutes a key mechanism by which healthy tissues are protected from NK cell-mediated lysis. However, self-ligand recognition remains poorly understood within the prototypical NKR-P1 receptor family. Here we report the structure of the inhibitory NKR-P1B receptor bound to its cognate host ligand, Clr-b. NKR-P1B and Clr-b interact via a head-to-head docking mode through an interface that includes a ...[more]