Ontology highlight
ABSTRACT:
SUBMITTER: Oba S
PROVIDER: S-EPMC6218490 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Oba Shigeyoshi S Ayuzawa Nobuhiro N Nishimoto Mitsuhiro M Kawarazaki Wakako W Ueda Kohei K Hirohama Daigoro D Kawakami-Mori Fumiko F Shimosawa Tatsuo T Marumo Takeshi T Fujita Toshiro T
Scientific reports 20181105 1
Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylation of Tgfb1 DNA and upregulation of Tgfb1 mRNA progressed simultaneously. USF1 binding site in Tgfb1 promoter region were demethylated, and binding of USF1 increased, with decreased binding of DNMT1 in db/db co ...[more]