Ontology highlight
ABSTRACT:
SUBMITTER: Li MX
PROVIDER: S-EPMC6218639 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Li Monica X MX Gelozia Shorena S Danmaliki Gaddafi I GI Wen Yurong Y Liu Philip B PB Lemieux M Joanne MJ West Frederick G FG Sykes Brian D BD Hwang Peter M PM
Biochemistry and biophysics reports 20181101
The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac troponin C (cTnC). Surprisingly, however, it binds only to the structural C-terminal domain of cTnC (cCTnC), and not to the regulatory N-terminal domain (cNTnC) that determines the calcium sensitivity of cardiac muscle. Physiologically, cTnC is a ...[more]