Ontology highlight
ABSTRACT:
SUBMITTER: Morozov AV
PROVIDER: S-EPMC6218844 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Morozov Alexey V AV Karpov Vadim L VL
Heliyon 20181001 10
Cell homeostasis and regulation of metabolic pathways are ensured by synthesis, proper folding and efficient degradation of a vast amount of proteins. Ubiquitin-proteasome system (UPS) degrades most intracellular proteins and thus, participates in regulation of cellular metabolism. Within the UPS, proteasomes are the elements that perform substrate cleavage. However, the proteasomes in the organism are diverse. Structurally different proteasomes are present not only in different types of cells, ...[more]