Single sample scoring of molecular phenotypes.
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ABSTRACT:
SUBMITTER: Foroutan M
PROVIDER: S-EPMC6219008 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Single sample scoring of molecular phenotypes.
Foroutan Momeneh M Bhuva Dharmesh D DD Lyu Ruqian R Horan Kristy K Cursons Joseph J Davis Melissa J MJ
BMC bioinformatics 20181106 1
<h4>Background</h4>Gene set scoring provides a useful approach for quantifying concordance between sample transcriptomes and selected molecular signatures. Most methods use information from all samples to score an individual sample, leading to unstable scores in small data sets and introducing biases from sample composition (e.g. varying numbers of samples for different cancer subtypes). To address these issues, we have developed a truly single sample scoring method, and associated R/Bioconducto ...[more]
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