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Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer.

ABSTRACT: BACKGROUND:Dose escalation of conventionally fractionated radiation therapy (CFRT) above 45-54 Gy has an unclear survival benefit. Prior National Cancer Database (NCDB) analyses have shown improved overall survival with induction chemotherapy (iC) prior to concurrent chemoradiation (CRT) in locally advanced pancreatic cancer. Our study compared dose-escalated CFRT with and without iC. METHODS:The NCDB was queried for primary stage III, cT4 N0-1 M0 LAPC treated with CRT with or without iC (2004-2015). CFRT was stratified by

SUBMITTER: Ma SJ 

PROVIDER: S-EPMC6219058 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer.

Ma Sung Jun SJ   Prezzano Kavitha M KM   Hermann Gregory M GM   Singh Anurag K AK  

Radiation oncology (London, England) 20181106 1

<h4>Background</h4>Dose escalation of conventionally fractionated radiation therapy (CFRT) above 45-54 Gy has an unclear survival benefit. Prior National Cancer Database (NCDB) analyses have shown improved overall survival with induction chemotherapy (iC) prior to concurrent chemoradiation (CRT) in locally advanced pancreatic cancer. Our study compared dose-escalated CFRT with and without iC.<h4>Methods</h4>The NCDB was queried for primary stage III, cT4 N0-1 M0 LAPC treated with CRT with or wit  ...[more]

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