Nucleic acid nanomedicines in Phase II/III clinical trials: translation of nucleic acid therapies for reprogramming cells.
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ABSTRACT:
SUBMITTER: Herrera VL
PROVIDER: S-EPMC6219437 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Nucleic acid nanomedicines in Phase II/III clinical trials: translation of nucleic acid therapies for reprogramming cells.
Herrera Victoria Lm VL Colby Aaron H AH Ruiz-Opazo Nelson N Coleman David G DG Grinstaff Mark W MW
Nanomedicine (London, England) 20180801 16
This review presents an integrated analysis of the current-state-of-the-art in nucleic acid nanotherapies and highlights the importance of nanotechnology in the delivery of nucleic acid therapies. While there is no one dominant nanodesign, the diversity of nanodesigns and delivery of different siRNAs, miRNA and DNA to inhibit more than 20 targets in seven disease states in Phase II/III clinical trials reflects the potential of nucleic acid therapies to treat intractable diseases and non-druggabl ...[more]
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