Ontology highlight
ABSTRACT:
SUBMITTER: Guo S
PROVIDER: S-EPMC6219484 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell death and differentiation 20180309 11
The role of GATA-binding protein 4 (GATA4) in neural crest cells (NCCs) is poorly defined. Here we showed that mouse NCCs lacking GATA4 exhibited developmental defects in craniofacial bone, teeth, and heart. The defects likely occurred due to decreased cell proliferation at the developmental stage. The in vitro results were consistent with the mouse model. The isobaric tags for relative and absolute quantitation assay revealed that BARX1 is one of the differentially expressed proteins after GATA ...[more]