Ontology highlight
ABSTRACT:
SUBMITTER: Orozco JIJ
PROVIDER: S-EPMC6219520 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181106 1
Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n = 96). Using supervised machine learning and integration of DNA methylomes from normal, primary, and metastatic tumor specimens (n = 1860), we unravel epigenetic signatures specific to each type of metastatic brain tumor and constructed a three-step DNA ...[more]