Dataset Information

Multilocus sequence typing of Candida albicans isolates from the oral cavities of patients undergoing haemodialysis.

ABSTRACT: This study evaluates the prevalence, diversity, and genetic profiles of Candida albicans isolates recovered from the oral cavities of haemodialysis patients. Oral swab samples were obtained from haemodialysis patients (n = 126) and healthy control subjects (n = 233) and Candida species were characterised. There was no significant difference between the haemodialysis and control groups in the prevalence of yeast carriers (23.6% vs. 31.0%, respectively) or C. albicans carriers (19.8% vs. 21.0%, respectively). C. albicans was the most populous species in both cohorts, followed by C. parapsilosis. C. parapsilosis and C. glabrata were more prevalent in the haemodialysis group than in the control group (C. parapsilosis 5.6% vs. 0.9% and C. glabrata 3.2% vs. 0.4%, respectively; P < 0.05). C. albicans isolates were analysed by multilocus sequence typing and the results were used to construct a phylogenetic tree. Most haemodialysis isolates were placed into Clade 4 (20.0%) and Clade 19 (16.0%) and most control isolates into Clade 8 (17%) and Clade 4 (14.9%). Differences in the strain abundance in each clade were not statistically significant between the two groups. Moreover, there was no significant association between the health status or diagnosis and either the sequence types or clades.

SUBMITTER: Gong YB

PROVIDER: S-EPMC6219599 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Multilocus sequence typing of Candida albicans isolates from the oral cavities of patients undergoing haemodialysis.

Gong Yan-Bing YB Jin Bo B Qi He H Zhang Rong R Zhang Xiu-Ying XY Yuan Ping P Zhao Tong-Xiang TX Geng Xing-Hua XH Zhang Min M Zheng Jian-Ling JL

Scientific reports 20181106 1

This study evaluates the prevalence, diversity, and genetic profiles of Candida albicans isolates recovered from the oral cavities of haemodialysis patients. Oral swab samples were obtained from haemodialysis patients (n = 126) and healthy control subjects (n = 233) and Candida species were characterised. There was no significant difference between the haemodialysis and control groups in the prevalence of yeast carriers (23.6% vs. 31.0%, respectively) or C. albicans carriers (19.8% vs. 21.0%, re ...[more]

PMID: 30401875

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Dataset Information

Multilocus sequence typing of Candida albicans isolates from the oral cavities of patients undergoing haemodialysis.

Publications

Multilocus sequence typing of Candida albicans isolates from the oral cavities of patients undergoing haemodialysis.

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