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A20-binding inhibitor of NF-?B (ABIN) 2 negatively regulates allergic airway inflammation.

ABSTRACT: TPL-2 MAP 3-kinase promotes inflammation in numerous mouse disease models and is an attractive anti-inflammatory drug target. However, TPL-2-deficient (Map3k8 -/-) mice develop exacerbated allergic airway inflammation to house dust mite (HDM) compared with wild type controls. Here, we show that Map3k8D270A/D270A mice expressing kinase dead TPL-2 had an unaltered response to HDM, indicating that the severe airway inflammation observed in Map3k8 -/- mice is not due to blockade of TPL-2 signaling and rather reflects a TPL-2 adaptor function. Severe allergic inflammation in TPL-2-deficient mice was likely due to reduced levels of ABIN-2 (TNIP2), whose stability depends on TPL-2 expression. Tnip2E256K knock-in mutation, which reduced ABIN-2 binding to A20, augmented the HDM-induced airway inflammation, but did not affect TPL-2 expression or signaling. These results identify ABIN-2 as a novel negative regulator of allergic airway responses and importantly indicate that TPL-2 inhibitors would not have unwanted allergic comorbidities.

SUBMITTER: Ventura S 

PROVIDER: S-EPMC6219730 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation.

Ventura Sonia S   Cano Florencia F   Kannan Yashaswini Y   Breyer Felix F   Pattison Michael J MJ   Wilson Mark S MS   Ley Steven C SC  

The Journal of experimental medicine 20181018 11

TPL-2 MAP 3-kinase promotes inflammation in numerous mouse disease models and is an attractive anti-inflammatory drug target. However, TPL-2-deficient (<i>Map3k8</i> <sup>-/-</sup>) mice develop exacerbated allergic airway inflammation to house dust mite (HDM) compared with wild type controls. Here, we show that <i>Map3k8<sup>D270A/D270A</sup></i> mice expressing kinase dead TPL-2 had an unaltered response to HDM, indicating that the severe airway inflammation observed in <i>Map3k8</i> <sup>-/-<  ...[more]

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