Ontology highlight
ABSTRACT:
SUBMITTER: McCoy RC
PROVIDER: S-EPMC6219754 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
McCoy Rajiv C RC Wakefield Jon J Akey Joshua M JM
Cell 20170201 5
Regulatory variation influencing gene expression is a key contributor to phenotypic diversity, both within and between species. Unfortunately, RNA degrades too rapidly to be recovered from fossil remains, limiting functional genomic insights about our extinct hominin relatives. Many Neanderthal sequences survive in modern humans due to ancient hybridization, providing an opportunity to assess their contributions to transcriptional variation and to test hypotheses about regulatory evolution. We d ...[more]