Ontology highlight
ABSTRACT:
SUBMITTER: Gradov DV
PROVIDER: S-EPMC6219852 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Industrial & engineering chemistry research 20180910 40
Computational fluid dynamics is a powerful method for scale-up of reactors although it is still challenging to fully embrace hydrodynamics and biological complexities. In this article, an aerobic fermentation of <i>Pichia pastoris</i> cells is modeled in a batch OKTOP®9000 reactor. The 800 m<sup>3</sup> industrial scale reactor is equipped with a radial impeller, designed by Outotec Oy for gas dispersion in the draft tube reactor. Measured <i>N</i> <sub><i>p</i></sub> of the impeller is used in ...[more]