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Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis.


ABSTRACT: BACKGROUND:The association between obesity and rising incidence of hepatocellular carcinoma (HCC) in the USA has been documented; however, the role of bariatric surgery remains less clear. AIM:To evaluate the cross-sectional association of prior-bariatric surgery and HCC. METHODS:The United States Nationwide Inpatient Sample (NIS) database was queried from 2004 to 2014 for discharges with a diagnosis of morbid obesity. Primary outcomes of interest were HCC and in-hospital mortality rate. Secondary outcomes were length of stay and cost. Baseline characteristics were balanced using propensity score matching (PSM). Using Poisson and logistic regressions, adjusted HCC prevalence ratio (PR) and mortality odds ratio (OR) were derived in patients with prior-bariatric surgery compared to those without bariatric surgery. RESULTS:Of the 2,881,414 patients included in our study, 267,082 (9.3%) underwent bariatric surgery. From 2004 to 2014, there was a threefold increase in age-adjusted prevalence of HCC from 27 per 100,000 to 72 per 100,000 (PTrend < 0.001). After PSM, 230,956 patients with prior-bariatric surgery were matched with 230,956 patients without bariatric surgery. Prior-bariatric surgery was associated with lower prevalence of HCC (PR 0.11; 95% CI, 0.03-0.48; P?

SUBMITTER: Njei B 

PROVIDER: S-EPMC6219901 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis.

Njei Basile B   McCarty Thomas R TR   Sharma Prabin P   Lange Andrew A   Najafian Nilofar N   Ngu Julius N JN   Ngomba Valmy E VE   Echouffo-Tcheugui Justin B JB  

Obesity surgery 20181201 12


<h4>Background</h4>The association between obesity and rising incidence of hepatocellular carcinoma (HCC) in the USA has been documented; however, the role of bariatric surgery remains less clear.<h4>Aim</h4>To evaluate the cross-sectional association of prior-bariatric surgery and HCC.<h4>Methods</h4>The United States Nationwide Inpatient Sample (NIS) database was queried from 2004 to 2014 for discharges with a diagnosis of morbid obesity. Primary outcomes of interest were HCC and in-hospital m  ...[more]

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