Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6219912 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Li Yue Y Guan Xiaoqun X Liu Weiren W Chen Hung-Lin HL Truscott Jamie J Beyatli Sonay S Metwali Ahmed A Weiner George J GJ Zavazava Nicholas N Blumberg Richard S RS Urban Joseph F JF Blazar Bruce R BR Elliott David E DE Ince M Nedim MN
Journal of immunology (Baltimore, Md. : 1950) 20181005 10
Helminths stimulate the secretion of Th2 cytokines, like IL-4, and suppress lethal graft-versus-host disease (GVHD) after bone marrow transplantation. This suppression depends on the production of immune-modulatory TGF-β and is associated with TGF-β-dependent in vivo expansion of Foxp3<sup>+</sup> regulatory T cells (Treg). In vivo expansion of Tregs is under investigation for its potential as a therapy for GVHD. Nonetheless, the mechanism of induced and TGF-β-dependent in vivo expansion of Treg ...[more]