Dataset Information

Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes.

ABSTRACT: In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO _x -modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4?×?4 micro-LEDs (dimensions of 220?×?270?×?50??m³, 700??m pitch) are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method. The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites (200??m in diameter and 700??m in pitch) modified by iridium oxide (IrO _x ). These two subparts can be aligned with alignment holes and glued back-to-back by epoxy, which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites. The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months, and the thermal property is specifically studied with different duty cycles, voltages, and frequencies. Additionally, the electrochemical results prove the reliability of the IrO _x -modified microelectrodes after repeated pressing or friction. To evaluate the tradeoff between flexibility and strength, two microelectrode arrays with thicknesses of 5 and 10??m are evaluated through simulation and experiment. The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small (rats and mice) and large animal subjects and ultimately in nonhuman primates.

SUBMITTER: Ji B

PROVIDER: S-EPMC6220173 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes.

Ji Bowen B Guo Zhejun Z Wang Minghao M Yang Bin B Wang Xiaolin X Li Wen W Liu Jingquan J

Microsystems & nanoengineering 20181008

In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO x -modified microelectrodes for synchronous photostimulation and neural signal recording is presented. The 4 × 4 micro-LEDs (dimensions of 220 × 270 × 50 μm3, 700 μm pitch) are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method. The recording electrodes share a similar fabrication process on the polyimide with 16 micro ...[more]

PMID: 31057915

Similar Datasets

Project description:The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits, which provides a promising approach for the study of progressive neurophysiological phenomena. Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the low mechanical stiffness of brain tissue for chronic reliable performance. However, lack of rigidity poses challenges for the accurate implantation of flexible neural probes with less invasiveness. Herein, we report a hybrid probe (Silk-Optrode) consisting of a silk protein optical fiber and multiple flexible microelectrode arrays. The Silk-Optrode can be accurately inserted into the brain and perform synchronized optogenetic stimulation and multichannel recording in freely behaving animals. Silk plays an important role due to its high transparency, excellent biocompatibility, and mechanical controllability. Through the hydration of the silk optical fiber, the Silk-Optrode probe enables itself to actively adapt to the environment after implantation and reduce its own mechanical stiffness to implant into the brain with high fidelity while maintaining mechanical compliance with the surrounding tissue. The probes with 128 recording channels can detect high-yield well-isolated single units while performing intracranial light stimulation with low optical losses, surpassing previous work of a similar type. Two months of post-surgery results suggested that as-reported Silk-Optrode probes exhibit better implant-neural interfaces with less immunoreactive glial responses and tissue lesions. A silk optical fiber-based Silk-Optrode probe consisting of a natural silk optical fiber and a flexible micro/nano electrode array is reported. The multifunctional soft probe can modify its own Young's modulus through hydration to achieve accurate implantation into the brain. The low optical loss and single-unit recording abilities allow simultaneous optogenetic stimulation and multichannel readout, which expands the applications in the operation and parsing of neural circuits in behavioral animals.

Dataset Information

Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes.

Publications

Flexible polyimide-based hybrid opto-electric neural interface with 16 channels of micro-LEDs and electrodes.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets