Ontology highlight
ABSTRACT:
SUBMITTER: Yang JM
PROVIDER: S-EPMC6220176 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yang Jr-Ming JM Bhattacharya Sayak S West-Foyle Hoku H Hung Chien-Fu CF Wu T-C TC Iglesias Pablo A PA Huang Chuan-Hsiang CH
Nature communications 20181107 1
The Ras-ERK signaling pathway regulates diverse cellular processes in response to environmental stimuli and contains important therapeutic targets for cancer. Recent single cell studies revealed stochastic pulses of ERK activation, the frequency of which determines functional outcomes such as cell proliferation. Here we show that ERK pulses are initiated by localized protrusive activities. Chemically and optogenetically induced protrusions trigger ERK activation through various entry points into ...[more]