Ontology highlight
ABSTRACT:
SUBMITTER: Merrikh CN
PROVIDER: S-EPMC6220195 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Merrikh Christopher N CN Merrikh Houra H
Nature communications 20181107 1
Most bacterial genes are encoded on the leading strand, co-orienting the movement of the replication machinery with RNA polymerases. This bias reduces the frequency of detrimental head-on collisions between the two machineries. The negative outcomes of these collisions should lead to selection against head-on alleles, maximizing genome co-orientation. Our findings challenge this model. Using the GC skew calculation, we reveal the evolutionary inversion record of all chromosomally encoded genes i ...[more]