Ontology highlight
ABSTRACT:
SUBMITTER: Title AC
PROVIDER: S-EPMC6220299 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Title Alexandra C AC Hong Sue-Jean SJ Pires Nuno D ND Hasenöhrl Lynn L Godbersen Svenja S Stokar-Regenscheit Nadine N Bartel David P DP Stoffel Markus M
Nature communications 20181107 1
The epithelial-to-mesenchymal transition (EMT) is an important mechanism for cancer progression and metastasis. Numerous in vitro and tumor-profiling studies point to the miR-200-Zeb1 axis as crucial in regulating this process, yet in vivo studies involving its regulation within a physiological context are lacking. Here, we show that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, initiates an EMT expression program, and promotes tumor invasion. Strik ...[more]