The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Neumann U
PROVIDER: S-EPMC6220303 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
Neumann Ulf U Ufer Mike M Jacobson Laura H LH Rouzade-Dominguez Marie-Laure ML Huledal Gunilla G Kolly Carine C Lüönd Rainer M RM Machauer Rainer R Veenstra Siem J SJ Hurth Konstanze K Rueeger Heinrich H Tintelnot-Blomley Marina M Staufenbiel Matthias M Shimshek Derya R DR Perrot Ludovic L Frieauff Wilfried W Dubost Valerie V Schiller Hilmar H Vogg Barbara B Beltz Karen K Avrameas Alexandre A Kretz Sandrine S Pezous Nicole N Rondeau Jean-Michel JM Beckmann Nicolau N Hartmann Andreas A Vormfelde Stefan S David Olivier J OJ Galli Bruno B Ramos Rita R Graf Ana A Lopez Lopez Cristina C
EMBO molecular medicine 20181101 11
The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states. The BACE-1 inhibitor CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP ...[more]
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