Ontology highlight
ABSTRACT:
SUBMITTER: Linder M
PROVIDER: S-EPMC6220323 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Linder Markus M Glitzner Elisabeth E Srivatsa Sriram S Bakiri Latifa L Matsuoka Kazuhiko K Shahrouzi Parastoo P Dumanic Monika M Novoszel Philipp P Mohr Thomas T Langer Oliver O Wanek Thomas T Mitterhauser Markus M Wagner Erwin F EF Sibilia Maria M
EMBO molecular medicine 20181101 11
Osteosarcoma (OS) is a rare tumor of the bone occurring mainly in young adults accounting for 5% of all childhood cancers. Because of the limited therapeutic options, there has been no survival improvement for OS patients in the past 40 years. The epidermal growth factor receptor (EGFR) is highly expressed in OS; however, its clinical relevance is unclear. Here, we employed an autochthonous c-Fos-dependent OS mouse model (H2<i>-c-fos</i>LTR) and human OS tumor biopsies for preclinical studies ai ...[more]