Ontology highlight
ABSTRACT:
SUBMITTER: Kolesnikova O
PROVIDER: S-EPMC6220335 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kolesnikova Olga O Ben-Shem Adam A Luo Jie J Ranish Jeff J Schultz Patrick P Papai Gabor G
Nature communications 20181107 1
Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promoter-bound yeast TFIID at a resolution better than 5 Å, except for a flexible domain. We position the crystal structures of several subunits and, in combination with cross-linking stu ...[more]