Pathways Linking Birth Weight and Insulin Sensitivity in Early Adolescence: A Double Mediation Analysis.

ABSTRACT:

Purpose

We examined pathways linking birth weight, weight gain from 0 to 2 years, and adiposity during childhood with insulin sensitivity in early adolescence.

Methods

Data were from a longitudinal cohort of 630 Quebec white children with a parental history of obesity (Quebec Adipose and Lifestyle Investigation in Youth study). In a subsample of children born at term (n = 395), weight-for-length z score (zWFL) from 0 to 2 years were computed. At 8 to 10 years, the percentage of body fat was assessed using dual energy X-ray absorptiometry. At 10 to 12 years, the Matsuda insulin sensitivity index (ISI) and the homeostasis model assessment for insulin resistance were determined. A linear regression-based approach for mediation analysis was used to estimate the distinct pathways

SUBMITTER: Van Hulst A 

PROVIDER: S-EPMC6220441 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature