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Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves.


ABSTRACT: BACKGROUND:Diffusion tensor imaging (DTI) has been applied in the lumbar and sacral nerves in vivo, but information about the reproducibility of this method is needed before DTI can be used reliably in clinical practice across centers. PURPOSE:In this multicenter study the reproducibility of DTI of the lumbosacral nerves in healthy volunteers was investigated. STUDY TYPE:Prospective control series. SUBJECTS:Twenty healthy subjects. FIELD STRENGTH/SEQUENCE:3T MRI. 3D turbo spin echo, and 3.0?mm isotropic DTI scan. ASSESSMENT:The DTI scan was performed three times (twice in the same session, intrascan reproducibility, and once after an hour, interscan reproducibility). At site 2, 1 week later, the protocol was repeated (interweek reproducibility). Fiber tractography (FT) of the lumbar and sacral nerves (L3-S2) was performed to obtain values for fractional anisotropy, mean, axial, and radial diffusivity. STATISTICAL TESTS:Reproducibility was determined using the intraclass correlation coefficient (ICC), and power calculations were performed. RESULTS:FT was successful and reproducible in all datasets. ICCs for all diffusion parameters were high for intrascan (ranging from 0.70-0.85), intermediate for interscan (ranging from 0.61-0.73), and interweek reliability (ranging from 0.58-0.62). There were small but significant differences between the interweek diffusivity values (P?

SUBMITTER: Haakma W 

PROVIDER: S-EPMC6221026 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves.

Haakma Wieke W   Hendrikse Jeroen J   Uhrenholt Lars L   Leemans Alexander A   Warner Thorup Boel Lene L   Pedersen Michael M   Froeling Martijn M  

Journal of magnetic resonance imaging : JMRI 20180209 4


<h4>Background</h4>Diffusion tensor imaging (DTI) has been applied in the lumbar and sacral nerves in vivo, but information about the reproducibility of this method is needed before DTI can be used reliably in clinical practice across centers.<h4>Purpose</h4>In this multicenter study the reproducibility of DTI of the lumbosacral nerves in healthy volunteers was investigated.<h4>Study type</h4>Prospective control series.<h4>Subjects</h4>Twenty healthy subjects.<h4>Field strength/sequence</h4>3T M  ...[more]

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