Unknown

Dataset Information

0

Prognostic value of 18F-fluorodeoxyglucose bone marrow uptake in patients with solid tumors: A meta-analysis.


ABSTRACT:

Background

Several studies have reported the prognostic value of F-fluorodeoxyglucose (F-FDG) bone marrow uptake (BMU) measured by F-FDG positron emission tomography (F-FDG PET) in various cancers. We performed a meta-analysis to evaluate the prognostic value of F-FDG BMU in patients with solid tumors.

Methods

Systematic searches of MEDLINE and Embase databases were performed using the keywords "F-FDG," "bone marrow," and "prognosis." All published human studies of the prognostic value of F-FDG BMU in patients with solid tumors were searched. The primary outcome was event-free survival (EFS), and the secondary endpoint was overall survival (OS); both of these were extracted directly from each study. The effects of F-FDG BMU on survival were assessed by using hazard ratios (HRs).

Results

Ten studies with 1197 patients (8 studies reporting EFS in 1096 patients and 7 studies reporting OS in 836 patients) were included. In the EFS analysis, the combined HR was 1.75 (95% confidence interval [CI]: 1.45-2.11, P?ConclusionThis meta-analysis has demonstrated that patients with a low level of F-FDG BMU have better EFS and OS than those with a high level of F-FDG BMU. Based on our results, we suggest that F-FDG BMU could be used as a biomarker for stratifying the risk of tumor progression in patients with solid tumors.

SUBMITTER: Jeong SY 

PROVIDER: S-EPMC6221657 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prognostic value of 18F-fluorodeoxyglucose bone marrow uptake in patients with solid tumors: A meta-analysis.

Jeong Shin Young SY   Kim Seong-Jang SJ   Pak Kyoungjune K   Lee Sang-Woo SW   Ahn Byeong-Cheol BC   Lee Jaetae J  

Medicine 20181001 43


<h4>Background</h4>Several studies have reported the prognostic value of F-fluorodeoxyglucose (F-FDG) bone marrow uptake (BMU) measured by F-FDG positron emission tomography (F-FDG PET) in various cancers. We performed a meta-analysis to evaluate the prognostic value of F-FDG BMU in patients with solid tumors.<h4>Methods</h4>Systematic searches of MEDLINE and Embase databases were performed using the keywords "F-FDG," "bone marrow," and "prognosis." All published human studies of the prognostic  ...[more]

Similar Datasets

2020-03-18 | GSE131769 | GEO
| S-EPMC7711777 | biostudies-literature
2020-03-18 | GSE135565 | GEO
| S-EPMC6598232 | biostudies-literature
| S-EPMC6675242 | biostudies-literature
| S-EPMC4818087 | biostudies-literature
| S-EPMC6704155 | biostudies-literature
| S-EPMC7072341 | biostudies-literature
| S-EPMC5458285 | biostudies-literature
| S-EPMC5915500 | biostudies-literature