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VE/VCO2 slope in lean and overweight women and its relationship to lean leg mass.


ABSTRACT: Ventilation/carbon dioxide production (VE/VCO2slope) is used clinically to determine cardiorespiratory fitness and morbidity in heart failure (HF). Previously, we demonstrated that lower lean leg mass is associated with high VE/VCO2slope during exercise in HF. In healthy individuals, we evaluated 1) whether VE/VCO2slope differed between lean and overweight women and 2) the relationship between lean leg mass and VE/VCO2slope in overweight sedentary (OWS), overweight trained (OWTR) and lean, trained (LTR) women. Methods:Gas exchange and ventilation were collected during a treadmill peak oxygen uptake test (VO2peak) in 40 women [26 OWS (29?±?7?yrs., mean?±?SD), 7 OWTR (33?±?5?yrs) and 7 LTR (26?±?6?yrs)]. Body composition was measured by dual X-ray absorptiometry. Results:VO2peak was highest in LTR (46.6?±?8?ml/kg/min) compared with OWTR (38.1?±?4.9?ml/kg/min) and OWS women (25.3?±?4.8?ml/kg/min, p??0.05). Higher lean leg mass was associated with lower VE/VCO2slope in overweight women (OWS?+?OWTR: r?=?-0.55, p?

SUBMITTER: Keller-Ross ML 

PROVIDER: S-EPMC6222036 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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V<sub>E</sub>/VCO<sub>2</sub> slope in lean and overweight women and its relationship to lean leg mass.

Keller-Ross Manda L ML   Chantigian Daniel P DP   Evanoff Nicholas N   Bantle Anne E AE   Dengel Donald R DR   Chow Lisa S LS  

International journal of cardiology. Heart & vasculature 20181106


Ventilation/carbon dioxide production (V<sub>E</sub>/VCO<sub>2slope</sub>) is used clinically to determine cardiorespiratory fitness and morbidity in heart failure (HF). Previously, we demonstrated that lower lean leg mass is associated with high V<sub>E</sub>/VCO<sub>2slope</sub> during exercise in HF. In healthy individuals, we evaluated 1) whether V<sub>E</sub>/VCO<sub>2slope</sub> differed between lean and overweight women and 2) the relationship between lean leg mass and V<sub>E</sub>/VCO<s  ...[more]

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