Ontology highlight
ABSTRACT:
SUBMITTER: Gu X
PROVIDER: S-EPMC6222100 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Gu Xin X Bridges Michael D MD Yan Yan Y de Waal Parker W PW Zhou X Edward XE Suino-Powell Kelly M KM Xu H Eric HE Hubbell Wayne L WL Melcher Karsten K
The Journal of biological chemistry 20180911 44
AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis and a promising drug target for managing metabolic diseases such as type 2 diabetes. Many pharmacological AMPK activators, and possibly unidentified physiological metabolites, bind to the allosteric drug and metabolite (ADaM) site at the interface between the kinase domain (KD) in the α-subunit and the carbohydrate-binding module (CBM) in the β-subunit. Here, using double electron-electron resonance (DEER) spectrosco ...[more]