Ontology highlight
ABSTRACT:
SUBMITTER: Amr AEE
PROVIDER: S-EPMC6222410 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Amr Abd El-Galil E AEE Abo-Ghalia Mohamed H MH Moustafa Gaber O GO Al-Omar Mohamed A MA Nossier Eman S ES Elsayed Elsayed A EA
Molecules (Basel, Switzerland) 20180920 10
A series of macrocyclic pyrido-pentapeptide candidates <b>2</b>⁻<b>6</b> were synthesized by using <i>N</i>,<i>N</i>-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine <b>1a</b>,<b>b</b> as starting material. Structures of the newly synthesized compounds were established by IR, ¹H and <sup>13</sup>C-NMR, and MS spectral data and elemental analysis. The in-vitro cytotoxicity activity was investigated for all compounds against MCF-7 and HepG-2 cell lines and the majority of the compounds sho ...[more]