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Novel 5'-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides.

ABSTRACT: Here we report the synthesis and biological activity of new 5'-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound 3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound 3i induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential.

SUBMITTER: Klimenko AA

PROVIDER: S-EPMC6222425 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Novel 5'-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides.

Klimenko Anna A AA Matyugina Elena S ES Logashenko Evgeniya B EB Solyev Pavel N PN Zenkova Marina A MA Kochetkov Sergey N SN Khandazhinskaya Anastasia L AL

Molecules (Basel, Switzerland) 20181016 10

Here we report the synthesis and biological activity of new 5'-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound <b>3i</b>, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound <b>3i</b> induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential. ...[more]

PMID: 30332788

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