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New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii.

ABSTRACT: Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A⁻C (1⁻3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.

SUBMITTER: Ni L 

PROVIDER: S-EPMC6222710 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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New 18(4→3)<i>-Abeo</i>-Abietanoids from <i>Tripterygium wilfordii</i>.

Ni Lin L   Zang Ying-da YD   Yang Jing-Zhi JZ   Li Chuang-Jun CJ   Ma Jie J   Zhang Dong-Ming DM  

Molecules (Basel, Switzerland) 20180926 10

Three 18(4→3)<i>-abeo</i>-abietanoids, a new natural product and two new compounds, named tripordolides A⁻C (<b>1</b>⁻<b>3</b>), were isolated from the leaves of <i>Tripterygium wilfordii.</i> Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu <i>K</i>α radiation. Compounds <b>1</b> and <b>3</b> showed moderate inhibitory activities agai  ...[more]

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