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New 18(4?3)-Abeo-Abietanoids from Tripterygium wilfordii.

ABSTRACT: Three 18(4?3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A?C (1?3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu K? radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.

SUBMITTER: Ni L 

PROVIDER: S-EPMC6222710 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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New 18(4→3)<i>-Abeo</i>-Abietanoids from <i>Tripterygium wilfordii</i>.

Ni Lin L   Zang Ying-da YD   Yang Jing-Zhi JZ   Li Chuang-Jun CJ   Ma Jie J   Zhang Dong-Ming DM  

Molecules (Basel, Switzerland) 20180926 10

Three 18(4→3)<i>-abeo</i>-abietanoids, a new natural product and two new compounds, named tripordolides A⁻C (<b>1</b>⁻<b>3</b>), were isolated from the leaves of <i>Tripterygium wilfordii.</i> Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu <i>K</i>α radiation. Compounds <b>1</b> and <b>3</b> showed moderate inhibitory activities agai  ...[more]

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