Ontology highlight
ABSTRACT:
SUBMITTER: Nicholatos JW
PROVIDER: S-EPMC6223043 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nicholatos Justin W JW Francisco Adam B AB Bender Carolyn A CA Yeh Tiffany T Lugay Fraz J FJ Salazar Jairo E JE Glorioso Christin C Libert Sergiy S
Acta neuropathologica communications 20181108 1
Parkinson's disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in neuronal culture and brain tissue. We find that reduction of SIRT6 is partly responsible for neuroprotection afforded by nicotine. Additionally, SIRT6 abundance is greater in Parkinson's patient brains, and decreased ...[more]