The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients.

ABSTRACT:

Background

The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response as a potential prognostic model.

Methods

CEA levels were determined from baseline to progression. A χ² test was used to assess the correlation between CEA changes and tumor response. Univariate and multivariate COX models were used to explore the correlation of CEA changes to progression-free survival (PFS) and overall survival (OS).

Results

All 114 patients were divided into five groups according to CEA change pattern (A: patients had an initial fast CEA decrease that then turned into a slow increase; B: patients had an initial slow CEA decr

SUBMITTER: Yu P 

PROVIDER: S-EPMC6223053 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature