Dataset Information

The data on the aerobic training with or without calorie restriction and muscular levels of Irisin and muscular FNDC5 concentration in obese male Wistar rats.

ABSTRACT: The present data article aims at investigating the muscular levels of Irisin, FNDC5, and UCP1 in male Wistar rats during the aerobic exercise with or without calorie restriction (CR). Twenty four, 8-week-old male Wistar rats (190±16?g) were selected and purchased for the research. After obesity induction by high-fat diet, the animals were randomly divided into three groups: exercise EX (n = 8), EX-CR (n = 8) and CO as control (n = 8). EX exercised 6 sessions per week and EXCR exercise 3 sessions + 3 days caloric restriction per week. The Irisin (Cat.No:CK-E91266 & Intra-Assay: CV<10%), FNDC5 (Cat.No:CK-E91393 & Intra-Assay: CV<10%) levels were assessed by the special Rat ELISA Kit (EASTBIOPHARM, China, under licensed by the United States). Muscular Irisin concentrations in EX group were higher than other groups. In addition, FNDC5 concentrations in EX group was higher than those in other groups.

SUBMITTER: Shirvani H

PROVIDER: S-EPMC6223192 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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The data on the aerobic training with or without calorie restriction and muscular levels of Irisin and muscular FNDC5 concentration in obese male Wistar rats.

Shirvani Hossein H Delpasand Alireza A Bazgir Behzad B

Data in brief 20181022

The present data article aims at investigating the muscular levels of Irisin, FNDC5, and UCP1 in male Wistar rats during the aerobic exercise with or without calorie restriction (CR). Twenty four, 8-week-old male Wistar rats (190±16 g) were selected and purchased for the research. After obesity induction by high-fat diet, the animals were randomly divided into three groups: exercise EX (n = 8), EX-CR (n = 8) and CO as control (n = 8). EX exercised 6 sessions per week and EXC ...[more]

PMID: 30426041

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Project description:Background: FNDC5 belongs to the family of proteins called fibronectin type III domain-containing which carry out a variety of functions. The expression of FNDC5 is associated with the occurrence and development of tumors. However, the role of FNDC5 in gastric cancer remains relatively unknown. Methods: In the research, the expression of FNDC5 and its value for the prognosis of gastric cancer patients were observed with the TCGA database and GEO datasets of gastric cancer patients. The role of FNDC5 in the regulation of gastric cancer cells proliferation, invasion, and migration was determined. WGCNA and Enrichment analysis was performed on genes co-expressed with FNDC5 to identify potential FNDC5-related signaling pathways. Meanwhile, the LASSO Cox regression analysis based on FNDC5-related genes develops a risk score to predict the survival of gastric cancer patients. Results: The expression of FNDC5 was decreased in gastric cancer tissues compared to normal gastric tissues. However, survival analysis indicated that lower FNDC5 mRNA levels were associated with better overall survival and disease-free survival in gastric cancer patients. Meanwhile, a significant negative correlation was found between FNDC5 and the abundance of CD4+ memory T cells in gastric cancer. In vitro overexpression of FNDC5 inhibits the migration and invasion of gastric cancer cells, without affecting proliferation. Finally, A two-gene risk score module based on FNDC5 co-expressed gene was built to predict the overall clinical ending of patients. Conclusion: FNDC5 is low expressed in gastric cancer and low FNDC5 predicts a better prognosis. The better prognosis of low FNDC5 expression may be attributed to the increased number of CD4+ memory activated T-cell infiltration in tumors, but the exact mechanism of the effect needs to be further explored. Overexpressing FNDC5 inhibits the invasion and migration of gastric cancer but does not affect proliferation. At last, we constructed a clinical risk score model composed of two FNDC5-related genes, and this model may help lay the foundation for further in-depth research on the individualized treatment of gastric cancer patients.

Dataset Information

The data on the aerobic training with or without calorie restriction and muscular levels of Irisin and muscular FNDC5 concentration in obese male Wistar rats.

Publications

The data on the aerobic training with or without calorie restriction and muscular levels of Irisin and muscular FNDC5 concentration in obese male Wistar rats.

Similar Datasets

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