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Nanoparticles applied to cancer immunoregulation.

ABSTRACT: Aim:In recent years, we have seen a considerable increase in the relevance of nanostructures for the safe delivery of therapeutic agents and their capacity as an immunomodulatory tool. Materials and methods:Potential clinical applications related to their unique structural properties have been described in the evolving landscape of immunotherapy. Results:This review briefly summarizes the evidence for the role of nanoparticles in regulating the immune response. Conclusions:Their main features to highlight how to provide an innovative means of biomedical application to oncology research.

SUBMITTER: Lopez-Campos F

PROVIDER: S-EPMC6223232 | biostudies-literature | 2019 Jan-Feb

REPOSITORIES: biostudies-literature

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Nanoparticles applied to cancer immunoregulation.

Lopez-Campos Fernando F Candini Danielle D Carrasco Eliseo E Berenguer Francés Miguel Angel MA

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology 20181102 1

<h4>Aim</h4>In recent years, we have seen a considerable increase in the relevance of nanostructures for the safe delivery of therapeutic agents and their capacity as an immunomodulatory tool.<h4>Materials and methods</h4>Potential clinical applications related to their unique structural properties have been described in the evolving landscape of immunotherapy.<h4>Results</h4>This review briefly summarizes the evidence for the role of nanoparticles in regulating the immune response.<h4>Conclusio ...[more]

PMID: 30425606

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Project description:Composite membranes play a very important role in the separation, concentration, and purification processes, but especially in membrane reactors and membrane bioreactors. The development of composite membranes has gained momentum especially through the involvement of various nanoparticles, polymeric, oxide, or metal, that have contributed to increasing their reactivity and selectivity. This paper presents the preparation and characterization of an active metal nanoparticle-support polymer type composite membrane, based on osmium nanoparticles obtained in situ on a polypropylene hollow fiber membrane. Osmium nanoparticles are generated from a solution of osmium tetroxide in tert-butyl alcohol by reduction with molecular hydrogen in a contactor with a polypropylene membrane. The composite osmium-polypropylene hollow fiber obtained membranes (Os-PPM) were characterized from the morphological and structural points of view: scanning electron microscopy (SEM), high resolution SEM (HR-SEM), energy dispersive spectroscopy analysis (EDAX), X-ray diffraction analysis (XRD), Fourier transform Infrared (FTIR) spectroscopy, thermal gravimetric analysis, and differential scanning calorimetry (TGA, DSC). The process performance was tested in a redox process of p-nitrophenol and 10-undecylenic (10-undecenoic) acid, as a target substance of biological or biomedical interest, in solutions of lower aliphatic alcohols in a membrane contactor with a prepared composite membrane. The characteristics of osmium nanoparticles-polypropylene hollow fiber membranes open the way to biological and biotechnological applications. These membranes do not contaminate the working environment, operate at relatively low temperatures, provide a large contact area between reactants, allow successive oxidation and reduction operations in the same module, and help to recover the reaction mass by ultrafiltration. The results obtained show that the osmium-polypropylene composite membrane allows the reduction of p-nitrophenol or the oxidation of 10-undecylenic acid, the conversion depending on the concentration in the lower aliphatic alcohol, the nature of the lower aliphatic alcohol, and the oxidant or reducing flow through the membrane contactor.

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Nanoparticles applied to cancer immunoregulation.

Publications

Nanoparticles applied to cancer immunoregulation.

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