Ontology highlight
ABSTRACT:
SUBMITTER: Yeh YS
PROVIDER: S-EPMC6223239 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yeh Yu-Sheng YS Jheng Huei-Fen HF Iwase Mari M Kim Minji M Mohri Shinsuke S Kwon Jungin J Kawarasaki Satoko S Li Yongjia Y Takahashi Haruya H Ara Takeshi T Nomura Wataru W Kawada Teruo T Goto Tsuyoshi T
iScience 20181021
The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue is known as a major site for cholesterol storage; however, the role of the local mevalonate pathway and its synthesized isoprenoids remains unclear. In this study, adipose-specific mevalonate pathway-disrupted (aKO) mice were generated through knockout of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). aKO mice showed serious lipodystrophy accompanied with glucose and lipid metabolic ...[more]