Ontology highlight
ABSTRACT:
SUBMITTER: Vendramin R
PROVIDER: S-EPMC6223542 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Vendramin Roberto R Verheyden Yvessa Y Ishikawa Hideaki H Goedert Lucas L Nicolas Emilien E Saraf Kritika K Armaos Alexandros A Delli Ponti Riccardo R Izumikawa Keichi K Mestdagh Pieter P Lafontaine Denis L J DLJ Tartaglia Gian Gaetano GG Takahashi Nobuhiro N Marine Jean-Christophe JC Leucci Eleonora E
Nature structural & molecular biology 20181029 11
Synchronization of mitochondrial and cytoplasmic translation rates is critical for the maintenance of cellular fitness, with cancer cells being especially vulnerable to translational uncoupling. Although alterations of cytosolic protein synthesis are common in human cancer, compensating mechanisms in mitochondrial translation remain elusive. Here we show that the malignant long non-coding RNA (lncRNA) SAMMSON promotes a balanced increase in ribosomal RNA (rRNA) maturation and protein synthesis i ...[more]