Dataset Information

Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.

ABSTRACT:

Introduction

Although sleep-disordered breathing has been found to be associated with higher urine albumin excretion, this association has not been evaluated in Hispanic/Latino populations, which experience a high burden of end-stage renal disease compared with non-Hispanics. We evaluated the association of sleep-disordered breathing with prevalent albuminuria among US Hispanics/Latinos.

Methods

This was a cross-sectional study of baseline data from participants in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based study that enrolled 16,415 adults in 4 US communities. Sleep-disordered breathing was assessed using a home sleep apnea monitor for overnight recording and was defined using 3 thresholds of the apnea-hypopnea index (AHI; 3% desaturation): ?5, ?15, and ?30. Albuminuria was defined as a urine albumin-to-creatinine ratio of ?30 mg/g.

Results

There were 12,572 participants with complete data available for analysis. The age- and sex-adjusted prevalence of albuminuria was 9.1%. Mean age was 41 years, and 48% were men. Age- and sex-adjusted prevalence of sleep-disordered breathing was higher among individuals with albuminuria compared with those without albuminuria (36% vs. 25% had AHI ?5, 18% vs. 9% had AHI ?15, and 9% vs. 4% had AHI ?30). In multivariable logistic regression analyses, AHIs ?5, ?15, and ?30 were associated with greater odds of albuminuria compared with those with AHIs <5, <15, and <30 (odds ratio [OR] 1.42, 95% confidence interval [CI]: 1.14-1.76; OR: 1.71, 95% CI: 1.33-2.20; and OR 1.93, 95% CI 1.34-2.79), respectively. This association varied by Hispanic/Latino background group.

Conclusion

In US Hispanic/Latinos, sleep-disordered breathing was independently associated with higher odds of prevalent albuminuria.

SUBMITTER: Ricardo AC

PROVIDER: S-EPMC6224780 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.

Ricardo Ana C AC Chen Jinsong J Singh Manpreet M Heiss Gerardo G Raij Leopoldo L Ramos Alberto A Redline Susan S Rosas Sylvia E SE Shah Neomi N Sotres-Alvarez Daniela D Zee Phyllis P Daviglus Martha M Lash James P JP

Kidney international reports 20180623 6

<h4>Introduction</h4>Although sleep-disordered breathing has been found to be associated with higher urine albumin excretion, this association has not been evaluated in Hispanic/Latino populations, which experience a high burden of end-stage renal disease compared with non-Hispanics. We evaluated the association of sleep-disordered breathing with prevalent albuminuria among US Hispanics/Latinos.<h4>Methods</h4>This was a cross-sectional study of baseline data from participants in the Hispanic Co ...[more]

PMID: 30450454

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Project description:ObjectiveTo examine the association between sleep-disordered breathing and stroke outcomes, and determine the contribution of sleep-disordered breathing to outcome disparities in Mexican Americans.MethodsIschemic stroke patients (n = 995), identified from the population-based Brain Attack Surveillance in Corpus Christi Project (2010-2015), were offered participation in a sleep-disordered breathing study including a home sleep apnea test (ApneaLink Plus). Sleep-disordered breathing (respiratory event index ≥10) was determined soon after stroke. Neurologic, functional, cognitive, and quality of life outcomes were assessed at 90 days poststroke. Regression models were used to assess associations between sleep-disordered breathing and outcomes, adjusted for sociodemographics, prestroke function and cognition, health-risk behaviors, stroke severity, and vascular risk factors.ResultsMedian age was 67 years (interquartile range [IQR] = 59-78); 62.1% were Mexican American. Median respiratory event index was 14 (IQR = 6-25); 62.8% had sleep-disordered breathing. Sleep-disordered breathing was associated with worse functional outcome (mean difference in activities of daily living/instrumental activities of daily living score = 0.15, 95% confidence interval [CI] = 0.01-0.28) and cognitive outcome (mean difference in modified Mini-Mental State Examination = -2.66, 95% CI = -4.85 to -0.47) but not neurologic or quality of life outcomes. Sleep-disordered breathing accounted for 9 to 10% of ethnic differences in functional and cognitive outcome and was associated with cognitive outcome more strongly for Mexican Americans (β = -3.97, 95% CI = -6.63 to -1.31) than non-Hispanic whites (β = -0.40, 95% CI = -4.18 to 3.39, p-interaction = 0.15).InterpretationSleep-disordered breathing is associated with worse functional and cognitive function at 90 days poststroke. These outcomes are reasonable endpoints for future trials of sleep-disordered breathing treatment in stroke. If effective, sleep-disordered breathing treatment may somewhat lessen ethnic stroke outcome disparities. ANN NEUROL 2019;86:241-250.

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Dataset Information

Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.

Introduction

Methods

Results

Conclusion

Publications

Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.

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