Ontology highlight
ABSTRACT:
SUBMITTER: Francini CM
PROVIDER: S-EPMC6225123 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Francini Cinzia Maria CM Musumeci Francesca F Fallacara Anna Lucia AL Botta Lorenzo L Molinari Alessio A Artusi Roberto R Mennuni Laura L Angelucci Adriano A Schenone Silvia S
Molecules (Basel, Switzerland) 20180917 9
Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates are currently in clinical trials. We previously reported a small library of 4-aminoimidazole and 2-aminothiazole derivatives active as Src family kinase (SFK) inhibitors. Starting from these results, we decided to perform an optimization study applying ...[more]