Ontology highlight
ABSTRACT:
SUBMITTER: Luk IY
PROVIDER: S-EPMC6225137 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Luk Ian Y IY Reehorst Camilla M CM Mariadason John M JM
Molecules (Basel, Switzerland) 20180830 9
The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are defined by their highly conserved ETS DNA binding domain and predominant epithelial-specific expression profile. ESE transcription factors maintain normal cell homeostasis and differentiation of a number of epithelial tissues, and their genetic alteration and deregulated expression has been linked to the progression of several epithelial cancers. Herein we review the normal function of the ESE transcription f ...[more]