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Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert.

ABSTRACT: Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.

SUBMITTER: Ardiles A

PROVIDER: S-EPMC6225235 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert.

Ardiles Alejandro A Barrientos Ruth R Simirgiotis Mario J MJ Bórquez Jorge J Sepúlveda Beatriz B Areche Carlos C Areche Carlos C

Molecules (Basel, Switzerland) 20180915 9

Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolate ...[more]

PMID: 30223578

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Dataset Information

Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert.

Publications

Gastroprotective Activity of <i>Parastrephia quadrangularis</i> (Meyen), Cabrera from the Atacama Desert.

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