A Novel Substance P-Based Hydrogel for Increased Wound Healing Efficiency.
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ABSTRACT:
SUBMITTER: Kim DJ
PROVIDER: S-EPMC6225281 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
A Novel Substance P-Based Hydrogel for Increased Wound Healing Efficiency.
Kim Da Jung DJ Jang Ji Hae JH Jang Song Sun SS Lee Jungsun J
Molecules (Basel, Switzerland) 20180831 9
The neuropeptide substance P (SP) is known to stimulate wound healing by regulating the production of relevant cytokines as well as cell proliferation and migration. However, the therapeutic application of SP is limited by its low stability under biological conditions and oxidation during purification, formulation, and storage. To address this problem, we developed a novel formulation of SP as an SP gel, and investigated its wound healing activity both in vitro and in vivo. SP in SP gel was stab ...[more]
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